Regeneration of muscle tissues

In the cell-based tissue engineering of muscle tissues, different types of autologous muscle cells are often used as a cell source. However, the removal of muscle tissue for generating creates another muscle defect and can result in high morbidity. Melanie and her team developed several methods to differentiate human adipose and bone marrow-derived MSCs into smooth muscle cells having contractile function both in vitro and via biomaterial-based bio-responsive drug delivery vehicles.

Professor Melanie Hart, Ph.D.

Dept. of Orthopedics and Trauma Surgery Freiburg University Medical Center

Section Head, Immunomodulation and Regenerative Medicine


Habilitation at the Eberhard Karls University of Tübingen, Germany

Doctor of Philosophy (Immunology and Microbiology), Rush University Medical Center, Chicago, USA

Bachelor of Science in Applied Biology / Pre-Medicine, Ferris State University, Big Rapids, Michigan, USA


Harvard Medical School, Brigham and Women’s Hospital, Boston, USA

Tübingen University Medical Center and BG Trauma Center Tübingen, Germany


Assistant Professor at Harvard Medical School, Brigham and Women’s Hospital, Boston, USA