Prediction of macrophage phenotype and IL-10 production

To advance our understanding of how macrophages respond to environmental cues, Dr. Hart uses a novel but simple and cost-effective approach to predict macrophage phenotype and their IL-10 content by using quantitative geometrical features of cell morphology as a predictor. Her group aims to use this image-based artificial-intelligence-assisted classification method as a general strategy for predicting a large range of macrophage phenotypes with different functions in response to different environment cues but also for prediction of IL-10 production, with the aim of improving our understanding of how cell morphology relates to cytokine biology.

Professor Melanie Hart, Ph.D.

Dept. of Orthopedics and Trauma Surgery Freiburg University Medical Center

Section Head, Immunomodulation and Regenerative Medicine


Habilitation at the Eberhard Karls University of Tübingen, Germany

Doctor of Philosophy (Immunology and Microbiology), Rush University Medical Center, Chicago, USA

Bachelor of Science in Applied Biology / Pre-Medicine, Ferris State University, Big Rapids, Michigan, USA


Harvard Medical School, Brigham and Women’s Hospital, Boston, USA

Tübingen University Medical Center and BG Trauma Center Tübingen, Germany


Assistant Professor at Harvard Medical School, Brigham and Women’s Hospital, Boston, USA