The computer-aided design and computer-aided manufacturing (CAD/CAM) of dental devices such as complete dentures increasingly replace conventional manual fabrication processes, as the CAD/CAM protocols improve among others the predictability of the treatment outcome. Here, resin-based fabrication is currently the most commonly used process for complete CAD/CAM dentures. Since residual monomer release from CAD/CAM materials may occur from the finished part, we aim at identifying potential chemical components released from the additively manufactured dental devices and examining their biological effect on gingival oral tissue cells. To reach this goal we work in close cooperation with our colleagues in the CAD/CAM-based biomaterial research field and analytical laboratories in the field of clinical pharmacy and industry.